Yeast cell cycle


How does the cell cycle communicate with metabolism? What happens to the translation rate when the cellular volume increases? How are the cell cycle transitions regulated? How does the collected empirical knowledge reflect the cyclic properties of the cell cycle?

These are research questions we study in different projects.










  1. M À Adrover, Z Zi, A Duch, J Schaber, A González-Novo, J Jimenez, M Nadal-Ribelles, J Clotet, E Klipp and F Posas.
    Time-dependent quantitative multicomponent control of the G₁-S network by the stress-activated protein kinase Hog1 upon osmostress.
    Sci. Signal. 4 (192):ra63, September 2011.

  2. M Barberis, C Linke, M À Adrover, A González-Novo, H Lehrach, S Krobitsch, F Posas and E Klipp.
    Sic1 plays a role in timing and oscillatory behaviour of B-type cyclins.
    Biotechnol. Adv. 30 (1):108–130, 2012.

  3. G Schreiber, M Barberis, S Scolari, C Klaus, A Herrmann and E Klipp.
    Unraveling interactions of cell cycle-regulating proteins Sic1 and B-type cyclins in living yeast cells: a FLIM-FRET approach.
    FASEB J. 26 (2):546–554, February 2012.

  4. T W Spiesser, C Müller, G Schreiber, M Krantz and E Klipp.
    Size homeostasis can be intrinsic to growing cell populations and explained without size sensing or signalling.
    FEBS J. 279 (22):4213–4230, November 2012.

  5. T W Spiesser, C Kühn, M Krantz and E Klipp.
    Bud-localization of CLB2 mRNA can constitute a growth rate dependent daughter sizer.
    PLoS Comput. Biol. 11 (4):e1004223, 2015.

  6. C Linke, A Chasapi, A González-Novo, I Al Sawad, S Tognetti, E Klipp, M Loog, S Krobitsch, F Posas, I Xenarios and M Barberis.
    A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle.
    npj Syst. Biol. Appl. 3:7, 2017.








Einstein Foundation



Janelia research campus (USA)

Naama Barkai, Weizmann Institute of Science Rehovot (Israel)






Humboldt-Universität zu Berlin, Institute of Biology,
Theoretical Biophysics, 10099 Berlin, Germany